Format single-cell RNA eQTL data for analysis

This function processes single-cell eQTL data from the OneK1K project for a specific cell type. It uses a mapping data frame to find the path to the relevant eQTL summary statistics file, reads the data, and formats it for use with the TwoSampleMR package.

Usage

format_single_cell_onek1k(onek1k_mapping, onek1k_cell_type)

Arguments

onek1k_mapping

A data frame containing mapping information for OneK1K eQTL data. Must contain 'cell_type' and 'path_to_eqtl_file' columns.

onek1k_cell_type

Character string. The name of the cell type to be processed (e.g., "CD4 Naive"). This must correspond to an entry in the 'cell_type' column of onek1k_mapping.

Value

A data frame of the formatted eQTL data, ready for use as an "exposure" dataset in TwoSampleMR.

Examples

if (FALSE) { # \dontrun{
# Create a dummy mapping data frame
mapping_df <- data.frame(
  cell_type = "CD4 Naive",
  path_to_eqtl_file = "path/to/your/eqtl_data.tsv.gz"
)
# Run the function
formatted_eqtls <- format_single_cell_onek1k(
  onek1k_mapping = mapping_df,
  onek1k_cell_type = "CD4 Naive"
)
} # }